美国男子接受猪肾脏移植近9个月 创下新纪录

Core Insights - A 67-year-old patient in the U.S. underwent a pig kidney transplant that lasted nearly 9 months, setting a new record for the survival duration of genetically edited pig kidneys in human trials [1][2] - The pig kidney was genetically modified with 69 edits to reduce rejection risks and enhance compatibility with human biology [1] - Despite the advancements, the patient experienced organ rejection and side effects from immunosuppressive drugs, leading to the kidney's removal [1] Group 1: Transplant Details - The transplant was performed at Brigham and Women's Hospital on January 25, where the patient temporarily ceased dialysis after the procedure [1] - The kidney's survival duration of 9 months is significant compared to previous attempts with pig organs, which did not exceed a few months [2] Group 2: Research Implications - This trial provides valuable insights for future xenotransplantation research, which aims to address the shortage of human transplant organs [2] - Pigs are considered ideal candidates for organ donation due to their anatomical and physiological similarities to humans, although challenges remain [2]