美国男子接受猪肾脏移植近9个月 创下新纪录

Core Insights - A 67-year-old patient in the U.S. underwent a pig kidney transplant that lasted nearly 9 months, setting a new record for the survival duration of genetically edited pig kidneys in human trials [1] - The pig kidney was genetically modified with 69 edits to reduce rejection risks and improve compatibility with human organs [1] - Despite the advancements, the patient experienced organ rejection and side effects from immunosuppressive drugs, leading to the removal of the pig kidney [1] Group 1 - The transplant provided valuable insights for xenotransplantation research, highlighting the potential of genetically edited pig organs to address organ shortages [2] - Previous attempts to transplant genetically edited pig hearts, lungs, and livers into humans have not exceeded a few months of survival [2] - Pigs are considered ideal candidates for xenotransplantation due to the similarities in organ structure and physiological functions, although various risks and technical challenges remain [2]