Kiniksa Pharmaceuticals Reports Third Quarter 2025 Financial Results and Recent Portfolio Execution

Core Insights - Kiniksa Pharmaceuticals reported a significant increase in net product revenue for ARCALYST, reaching $180.9 million in Q3 2025, which represents a 61% year-over-year growth [1][7] - The company raised its 2025 net sales guidance for ARCALYST to between $670 million and $675 million, up from a previous estimate of $625 million to $640 million [2][13] - KPL-387 received Orphan Drug Designation from the FDA for the treatment of pericarditis, indicating potential for expanded treatment options in this area [1][15] Financial Results - Total revenue for Q3 2025 was $180.9 million, compared to $112.2 million in Q3 2024 [7][22] - Net income for Q3 2025 was $18.4 million, a turnaround from a net loss of $12.7 million in Q3 2024 [13][22] - Cash balance increased by $44.3 million in Q3 2025, totaling $352.1 million as of September 30, 2025 [1][13] Portfolio Execution - The average total duration of ARCALYST therapy for recurrent pericarditis increased to approximately 32 months by the end of Q3 2025, up from 27 months at the end of 2024 [7] - Kiniksa is on track to report data from the Phase 2 dose-focusing portion of the KPL-387 Phase 2/3 trial in the second half of 2026 [2][7] - KPL-1161 is undergoing IND-enabling development activities, targeting quarterly subcutaneous dosing [5][16] Market Position - Over 3,825 prescribers have written ARCALYST prescriptions for recurrent pericarditis since its launch, indicating strong market adoption [7] - The company aims to enhance its IL-1α & IL-1β inhibition franchise with the development of KPL-387, potentially expanding its market penetration [2][15]