中国工程院院士曹雪涛：新一轮创新药国家重大专项推动“四个转变” 预期2035年建成世界生物医药产业高地

Core Insights - The 10th Pharmaceutical Innovation and Investment Conference was held in Nanjing on October 26-27, highlighting advancements in China's drug development landscape [1] - The new phase of the "National Major Special Project for Innovative Drug Development" has been launched this year, building on the previous round of initiatives and achieving leapfrog development [1][2] - Significant breakthroughs have been made in major drug development, with 84 new class drugs approved, a substantial increase compared to prior to the implementation of related projects [1] Group 1 - The transition from a focus on imitation to independent creation in drug development has been fundamentally altered by the "Major New Drug Creation Major Special Project" from 2008 to 2020 [1] - China has gained strong international influence in specific fields such as Antibody-Drug Conjugates (ADC) and cell therapy [1] - The innovation capabilities of domestic companies have significantly improved, with some original drugs developed by local firms receiving FDA approval [1] Group 2 - The strategic planning for the new phase of the national drug development project emphasizes leveraging past experiences while targeting new high-peak areas [2] - The project aims to shift from single product development to a three-pronged approach focusing on products, talent, and platforms to enhance research capabilities [2] - The initiative will also focus on upstream innovation, addressing unmet clinical needs, and promoting forward-looking innovative approaches [2] Group 3 - The main tasks of the project will revolve around drug research connections, including new drug target discovery and traditional Chinese medicine development [3] - By 2035, the goal is to establish a self-controlled, efficient, and robust national drug innovation system, positioning China as a global center for new drug creation and biopharmaceutical industry [3]