创纪录，基因编辑猪肾在人体“工作”271天

Core Viewpoint - The successful transplantation of a genetically edited pig kidney into a human patient, Tim Andrews, has set a new record for survival duration, lasting 271 days, highlighting advancements in xenotransplantation and its potential to address organ shortages [1][2]. Group 1: Medical Advancements - Tim Andrews underwent a pig kidney transplant on January 25, which was genetically edited to enhance compatibility and reduce rejection risks [1]. - The pig kidney was edited at 69 sites, including the removal of genes that cause rejection and the addition of human genes to improve compatibility [1]. - Despite the advancements, Andrews experienced rejection reactions and had to have the kidney removed after 271 days due to the side effects of immunosuppressive drugs [2]. Group 2: Global Research Efforts - The U.S. has seen multiple attempts at xenotransplantation, with previous cases of pig kidney transplants lasting less than two months before rejection [1]. - Chinese medical teams are also making strides in this field, with a successful pig kidney transplant that has functioned for over 200 days, marking a significant achievement in Asia [2]. - Other organs, such as pig hearts, lungs, and livers, are being explored for transplantation to address the organ shortage crisis [3]. Group 3: Ethical and Research Considerations - There are ongoing concerns regarding the long-term health impacts of animal organ transplants on humans, as well as the quality of life for recipients [3]. - The field of xenotransplantation raises ethical, anthropological, and sociological questions that need to be addressed to ensure responsible implementation [3].