China Meheco(SH:600056) Di Yi Cai Jing·2025-10-30 10:43Core Insights - The Chinese pharmaceutical industry has made significant progress in innovation, with total licensing amounts for innovative drugs exceeding $100 billion in 2023, marking a historical high for a single year [1] - Despite these achievements, the fundamental research capabilities remain weak, necessitating urgent attention to enhance original innovation and core technology development [1][2] Group 1: Challenges in Innovation - Six major challenges facing Chinese innovative drugs include urgent medication needs for major chronic and infectious diseases, imbalance in disease spectrum matching, weak original innovation capacity, concentrated R&D efforts, lack of international clinical research layout, and the need for improved collaboration among national strategic scientific forces [2] - The proportion of potential first-in-class drugs in the pipeline for the top 20 multinational pharmaceutical companies globally is 38%, while for the top 20 Chinese companies, it is only 13% [2] - Current core technologies in biomedicine, such as antibody technology and CAR-T, are not originally developed in China, indicating a lack of sustainable, source-based technological output [2][6] Group 2: Evolution of Clinical Research - Over the past decade, there has been a significant transformation in China's oncology field, with Chinese doctors now becoming principal investigators in large international studies, a scenario unimaginable two decades ago [3][5] - Previously, Chinese doctors had limited participation in international clinical trials, often relegated to minor roles without decision-making power [4][6] Group 3: Need for Fundamental Research - To achieve self-reliance and strength in innovative drugs, China must enhance foundational research, which should primarily be driven by universities and research institutions rather than clinical doctors or small pharmaceutical companies [7] - Current collaboration between industry, academia, and research is often ineffective, leading to a disconnect between basic research and clinical needs [7] Group 4: Strategic Initiatives for Improvement - The new round of the "National Major Special Project for Innovative Drugs" will focus on four key transformations: shifting from product-oriented to capability-oriented development, emphasizing upstream innovation chains, prioritizing original drug development over generics, and focusing on unmet clinical needs [8]