人肾类器官首次与猪肾实现功能整合

Core Insights - An international research team led by the Catalonia Institute of Bioengineering has successfully combined human kidney organoids with live pig kidneys in vitro and transplanted them back into pigs, marking a significant milestone in regenerative medicine and personalized healthcare [1][2] - The study results were published in the latest issue of Nature Biomedical Engineering, paving the way for clinical trials using human stem cell-derived kidney organoids for cell therapy [1] Group 1 - Kidney organoids are three-dimensional microstructures cultivated from human stem cells, measuring only a few micrometers, capable of replicating major kidney structures and some functions, primarily used for kidney development research and drug testing [1] - Pig kidneys, structurally and functionally similar to human kidneys, provide a realistic environment for preclinical transplantation research [1] Group 2 - The study demonstrated that 24 and 48 hours post-transplant, human kidney organoids successfully integrated into pig kidney tissue, maintained viability, and did not trigger significant immune responses [2] - The transplanted kidneys functioned normally without signs of damage or toxicity, and physiological parameters could be monitored in real-time to detect any damage or rejection [2] Group 3 - The research introduced a systematic method for rapidly generating thousands of human kidney organoids in a short time without complex components, utilizing micro-aggregation and genetic engineering techniques for high-precision and controlled production [2]