跨物种哺乳动物脑细胞发育图谱绘成

Core Insights - The research presents the first detailed cross-species mammalian brain cell development atlas, providing unprecedented reference for understanding early brain formation and the origins of neurodevelopmental disorders [1][2][3] - Approximately 15% of children and adolescents are affected by neurodevelopmental disorders, highlighting the urgency of understanding critical periods of brain development [1] Group 1: Research Findings - The study, part of the BRAIN Initiative Cell Atlas Network (BICAN), integrates single-cell genomics, spatial transcriptomics, and advanced imaging techniques to construct a comprehensive brain cell atlas across multiple species [1] - A focus on GABAergic inhibitory neurons in the mouse forebrain revealed their migration process from birthplace to functional locations, which is crucial for motor, memory, and emotional regulation [2] - The research tracked over 770,000 single cells in the mouse visual cortex from embryonic to early adult stages, showing that brain cell diversification continues after birth, particularly during the initial visual experiences [2] Group 2: Implications for Future Research - The use of BARseq technology allowed for the mapping of gene expression profiles of millions of neurons, confirming the critical role of sensory experiences in brain region specialization [3] - The findings provide a solid framework for studying the origins of developmental disorders such as autism and schizophrenia, potentially leading to early diagnosis and targeted interventions [3]