IOVA Soars 28% on Narrower-Than-Expected Loss in Q3, Revenues Up Y/Y

Core Insights - Iovance Biotherapeutics reported a narrower loss of $0.25 per share for Q3 2025, compared to the Zacks Consensus Estimate of a loss of $0.29, and an improvement from a loss of $0.28 per share in the same quarter last year [1][7] - Quarterly revenues increased by 15% year over year to $67.5 million, although this figure fell short of the Zacks Consensus Estimate of $70.3 million [1][7] - The company experienced a significant gross margin increase to 43%, up from 5% in the previous quarter, attributed to cost optimization efforts [5][7] Revenue Breakdown - Amtagvi sales contributed approximately $57.5 million, reflecting a 37% year-over-year increase but missing the Zacks Consensus Estimate of $58 million [3] - Proleukin generated $10 million in sales, down 40% year over year, and also missed the Zacks Consensus Estimate of $15 million [3] Operating Costs - Research and development expenses rose to $75 million, a 12% increase from the previous year, driven by higher employee and clinical costs [4] - Selling, general, and administrative expenses decreased by 12% to nearly $36 million, primarily due to reduced stock compensation expenses [4] Financial Outlook - Iovance maintains its full-year product revenue guidance of $250 million to $300 million, anticipating significant growth in total product revenues for 2026 and beyond [9] - The company expects gross margins to improve through optimization of manufacturing capacity utilization over the next several years [9] Pipeline Developments - Regulatory applications for Amtagvi in melanoma are under review in Australia, Switzerland, and the UK, with potential approvals expected within two years [10] - Iovance is advancing its development programs for Amtagvi, including a phase III study in combination with Merck's Keytruda for advanced melanoma [11] - The company is also evaluating Amtagvi for other indications, including advanced non-squamous non-small cell lung cancer, with promising interim data reported [13][14]