国科大研发直接脱氨官能团化工艺

Core Viewpoint - The research team led by Zhang Xiaoheng from the University of Chinese Academy of Sciences has developed a groundbreaking method for direct deamination functionalization using N-nitrosamines, which challenges the traditional industrial processes that have been in use for 140 years [1] Summary by Relevant Sections Research Breakthrough - The new method allows for the direct transformation of aromatic amines into various C-X bonds (including carbon-halogen, carbon-oxygen, carbon-nitrogen, and carbon-carbon bonds) through the in-situ formation of N-nitrosamine intermediates under nitric acid mediation, followed by the removal of dinitrogen oxide [1] Industrial Implications - This innovative approach addresses several issues associated with the traditional stepwise strategy, such as the instability and explosive hazards of diazonium salts, significant copper consumption, and limited substrate compatibility [1] Practical Application - The research team has also developed a one-pot deamination cross-coupling strategy, enabling multiple cross-coupling reactions to be completed within the same reaction system by simply adding the corresponding coupling reagents to the deamination intermediate [1] Scalability - The new method can efficiently achieve kilogram-scale synthesis of target products using common laboratory reagents, making it applicable in pharmaceutical and materials manufacturing sectors [1]