Nasdaq Down Over 150 Points; Disney Shares Fall After Q4 Results - Applied Therapeutics (NASDAQ:APLT), Clearmind Medicine (NASDAQ:CMND)

Market Overview - U.S. stocks traded lower, with the Nasdaq Composite falling more than 150 points on Thursday. The Dow decreased by 0.08% to 48,216.64, the NASDAQ fell 0.75% to 23,231.95, and the S&P 500 dropped 0.40% to 6,823.53 [1] Company Performance - Walt Disney Co. (NYSE:DIS) shares fell approximately 5% after releasing its fiscal fourth-quarter 2025 results. The company reported adjusted EPS of $1.11, surpassing the consensus estimate of $1.04, but revenue remained flat year-over-year at $22.5 billion, slightly missing the analyst forecast of $22.7 billion [2] Sector Performance - Energy shares increased by 0.6% on Thursday, while communication services stocks declined by 1.2% [1] Notable Stock Movements - Mersana Therapeutics Inc (NASDAQ:MRSN) shares surged 207% to $27.20 following an acquisition announcement by Day One Biopharmaceuticals. Nuvve Holding Corp (NASDAQ:NVVE) shares rose 153% to $0.39 after an aggregation agreement in Japan. Clearmind Medicine Inc (NASDAQ:CMND) shares increased by 73% to $0.54 after receiving FDA approval for a clinical trial expansion [8] - Conversely, Korro Bio Inc (NASDAQ:KRRO) shares plummeted 79% to $6.74 after reporting third-quarter results and announcing a wind-down of R&D activities. Applied Therapeutics Inc (NASDAQ:APLT) shares fell 40% to $0.55 following third-quarter results, and EPWK Holdings Ltd (NASDAQ:EPWK) dropped 37% to $0.041 after announcing a share consolidation [8]