Persephone Biosciences Announces Topline Results from AMBROSIA Food as Medicine Study with Kroger Health

Core Insights - Persephone Biosciences announced topline results from the AMBROSIA Food as Medicine clinical study, which investigated the impact of diet and lifestyle on the microbiome in collaboration with Kroger Health [1][2] - The study identified three enterotypes, with one linked to increased BMI and poorer diet, and demonstrated that Medical Nutritional Therapy (MNT) can improve microbiome composition and facilitate enterotype switching [5][6] Study Overview - The AMBROSIA study is the largest to evaluate the impact of MNT on diet quality and gut microbiome, enrolling 546 participants aged 18-64 at high risk of colorectal cancer [2][5] - Participants were randomized into two groups: one receiving MNT for 4 months and the other serving as a control group with no dietary modifications [3] Key Findings - Enterotype 3, dominated by Prevotella, was associated with higher BMI, lower diet scores, and lower microbial diversity [6] - The MNT cohort showed higher final diet scores and greater movement between enterotypes compared to the control group after 4 months [6] - The study found a direct correlation between the number of MNT visits and the percentage of goals attained with diet scores [6] Implications for Healthcare - The findings suggest that MNT, combined with microbiome analysis, could enhance personalized nutrition and lead to better health outcomes [6] - The data from the AMBROSIA trial will also be used to assess the relationship between gut bacteria and colorectal cancer risk, which is a leading cause of cancer-related deaths in the U.S. [7]