美股开盘，三大股指大幅低开，道指跌0.78%，纳指跌1.42%，标普500指数跌1.07%

Group 1 - The U.S. stock market opened significantly lower, with the Dow Jones down 0.78%, the Nasdaq down 1.42%, and the S&P 500 down 1.07% [1] - Concerns from Federal Reserve officials regarding inflation remaining above target have led to a decline in the probability of a rate cut in December, falling below 50% for the first time [1] - Applied Materials saw a drop of over 7%, despite exceeding expectations for Q4 performance and Q1 guidance, with potential revenue reduction of $600 million by 2026 due to export restrictions to China [1] Group 2 - Cidara Therapeutics experienced a pre-market surge of 105% following the announcement that Merck will acquire the company for $221.5 per share in cash, with the deal expected to close in Q1 2026 [1] - Google shares fell nearly 3% after the company announced plans to appeal the European Commission's antitrust ruling and rejected the idea of splitting its business [1]