特定单基因突变会导致精神疾病

Core Insights - The study led by scientists from Leipzig University demonstrates that mutations in the GRIN2A gene can cause mental disorders, marking it as the first known single gene responsible for such conditions [1][1][1] Summary by Categories Research Findings - The research published in the journal Molecular Psychiatry analyzed data from 121 individuals with genetic variations in the GRIN2A gene [1] - Certain variants of the GRIN2A gene are associated not only with schizophrenia but also with other mental disorders [1] - Notably, some individuals affected by mental disorders only exhibit psychiatric symptoms, while GRIN2A mutations are typically linked to epilepsy or intellectual disabilities [1] Implications - The GRIN2A gene plays a crucial role in regulating the electrical excitability of nerve cells, with specific variants leading to reduced NMDA receptor activity, which is essential for brain signaling [1]