再生医学重大突破 用人类细胞构建三维骨髓组织模型

Core Insights - A research team from the University of Basel has developed a highly realistic three-dimensional bone marrow tissue model using human cells, marking a significant advancement in the field of blood cancer research and drug testing [2][3] - The new model replicates the complex structures of bone marrow, including blood vessels, bone cells, nerves, and immune cells, providing a new platform for research that overcomes the limitations of traditional animal models and simplified two-dimensional cell cultures [2][4] Summary by Sections - Research Breakthrough: The model is constructed using hydroxyapatite as a scaffold combined with induced pluripotent stem cells, allowing for the cultivation of a three-dimensional bone marrow tissue that closely resembles human tissue in both cellular composition and spatial structure [2] - Implications for Blood Cancer Research: The model can maintain human blood generation activity for several weeks, offering a more accurate simulation of human hematopoiesis, which is crucial for disease modeling and drug screening [2][3] - Ethical Considerations: This system is expected to reduce reliance on animal testing in blood cancer research, aligning with the principles of "replacement, reduction, refinement" in scientific research ethics [2] - Future Applications: The technology may extend to personalized medicine, allowing for the creation of patient-specific bone marrow models to test various therapies, although technical challenges remain before clinical application can be realized [3][4] - Potential Impact on Biomedical Research: This advancement represents a milestone in regenerative medicine and translational research, potentially addressing ethical dilemmas and time constraints in drug development [4]