再生医学重大突破！用人类细胞构建三维骨髓组织模型

Group 1 - The research team from the University of Basel has developed a highly realistic 3D bone marrow tissue model using human cells, which replicates the complex structures of blood vessels, bone cells, nerves, and immune cells, providing a new platform for blood cancer research, drug testing, and alternatives to animal testing [1] - The new model utilizes hydroxyapatite as a scaffold and combines it with induced pluripotent stem cells, allowing for the cultivation of a 3D bone marrow tissue that maintains human blood generation activity for several weeks, with a diameter of 8 millimeters and a thickness of 4 millimeters [1] - The project leader, Professor Ivan Martin, emphasized that while mouse models have laid the groundwork for bone marrow research, significant biological differences exist between humans and animals, making the new model more accurate for simulating human hematopoietic mechanisms, particularly in disease modeling and drug screening [1] Group 2 - This research not only provides a new tool for exploring the mechanisms of blood diseases but also marks a significant step in the field of in vitro simulation of complex organ functions, with potential future applications in personalized medicine [2] - The technology could allow for the construction of personalized bone marrow models using patients' own cells, enabling doctors to test different therapies in advance and tailor the best treatment plans for blood cancer patients [2] - The research team noted that while the current model is promising, it still faces technical challenges and will require further miniaturization for high-throughput drug testing to accommodate parallel experiments with multiple compounds [2]