中国首个异种器官移植猕猴存活超一年

Core Viewpoint - The first successful xenotransplantation of a pig kidney into a macaque has resulted in the recipient surviving for over a year, marking a significant advancement in addressing the global organ shortage issue [1][2]. Group 1: Research and Development - The experiment was conducted by the team led by Chen Gang at Tongji Hospital, Huazhong University of Science and Technology [1]. - This case is the first of its kind outside the United States, providing a crucial scientific foundation for solving clinical organ shortages [1]. - The research team has been working in the field of xenotransplantation since 1999 and has made significant progress, including the use of genetically edited pigs in 2019 [1]. Group 2: Challenges and Breakthroughs - Xenotransplantation faces significant challenges, including severe immune rejection reactions [1]. - The research team identified two key issues: porcine cytomegalovirus and precise immunosuppression, which they successfully addressed [1]. - The recipient macaque has stable physiological indicators and remains in good health after over a year [1]. Group 3: Future Prospects - Chen Gang expressed that xenotransplantation offers hope for terminally ill patients with no available organs and aims to address the global organ shortage [2]. - The team anticipates advancing this technology to clinical application within the next three to five years [2].