专家：前列腺癌患者应关注PSA 全程管理带来长期高质量生存

Core Viewpoint - Prostate cancer is increasingly recognized as a significant health issue among older men, with early detection and management through PSA screening being crucial for improving long-term survival and quality of life [1][2]. Group 1: Prostate Cancer Overview - Prostate cancer is a malignant tumor occurring in the prostate gland, often diagnosed in older men, particularly after retirement [1]. - The incidence of prostate cancer increases significantly after the age of 65, with many patients being diagnosed incidentally during orthopedic consultations for unrelated issues [1]. Group 2: PSA Screening and Diagnosis - PSA (Prostate-Specific Antigen) is the recommended biomarker for prostate cancer screening, requiring only a blood sample for testing [2]. - An increase in PSA levels does not definitively indicate prostate cancer, as conditions like benign prostatic hyperplasia or prostatitis can also elevate PSA [2]. - Continuous monitoring of PSA levels is essential, especially if there are no symptoms, as a consistent rise may indicate a higher risk of cancer [2]. Group 3: Treatment Options - Treatment strategies for prostate cancer vary based on whether the cancer has metastasized, with options including surgery, systemic therapy, and radiation [3]. - Surgical intervention is the most definitive treatment for localized prostate cancer, with robotic-assisted techniques improving outcomes related to urinary control [2][3]. - For patients with limited metastasis, combining systemic therapy with surgery can enhance long-term treatment effectiveness [3]. Group 4: Follow-Up and Management - Continuous management and follow-up are critical even after successful surgical intervention, as there remains a risk of recurrence [3]. - PSA levels are a vital indicator during follow-up, with lower levels suggesting better treatment response and longer survival [3]. Group 5: Advances in Treatment - The focus of current drug development is on new anti-androgen medications to address castration-resistant prostate cancer, aiming to prolong the time before resistance develops [4]. - Early administration of these new drugs is believed to stabilize the disease and improve the quality of life for patients [4]. Group 6: Patient Quality of Life - Most treatments for prostate cancer have manageable side effects, and patients are encouraged to maintain a balanced diet without specific restrictions related to cancer [5]. - Long-term effective treatment and management can lead to improved quality of life for prostate cancer patients [5].