基因编辑民猪培育成功

Core Viewpoint - The research teams from Heilongjiang Academy of Agricultural Sciences and Sun Yat-sen University have successfully developed the world's first single-gene and multi-gene edited Min pigs, marking a significant advancement in genetic editing for livestock breeding [1] Group 1: Single-Gene Editing Achievements - The teams achieved single-gene editing of the IGF2 gene, resulting in Min pigs with improved meat quality [1] - They also edited the BMP15 gene, leading to Min pigs with enhanced reproductive capabilities [1] Group 2: Multi-Gene Editing Achievements - The teams combined the BMP15, MSTN, and CD163 genes to create three-gene edited Min pigs that exhibit increased production, high reproductive capacity, and disease resistance [1] - Another combination of the TYR, SGK3, and GHRHR genes resulted in three-gene edited Min pigs characterized by hairlessness, albinism, and dwarfism [1] Group 3: Broader Implications and Future Research - The research also included the Five-Finger Mountain pig, resulting in growth-related PROP1 gene edited pigs and high reproductive capacity FecB gene edited pigs [1] - The findings provide new pathways for high-quality Min pig production and open new avenues for the breeding of medical model pigs and pet pigs, indicating significant theoretical and practical implications [1] - The teams plan to enhance trait evaluation of gene-edited pigs and continue research on other gene-edited pigs, contributing to the protection of local pig resources and the development of the life and health industry in China [1]