Globenewswire·2025-12-01 12:30Core Insights - Zorevunersen shows potential as a disease-modifying therapy for Dravet syndrome, supported by four years of clinical data and EEG assessments [1][2][3] Company Overview - Biogen Inc. is a leading biotechnology company focused on innovative science to develop new medicines [7] - Stoke Therapeutics specializes in RNA medicine aimed at restoring protein expression, with zorevunersen as its first investigational product [9] Product Information - Zorevunersen is an investigational antisense oligonucleotide targeting the underlying cause of Dravet syndrome by increasing NaV1.1 protein production [5] - The drug has received orphan drug designation and Breakthrough Therapy Designation from the FDA for Dravet syndrome [5] Clinical Studies - The ongoing EMPEROR Phase 3 study evaluates zorevunersen's efficacy in children with Dravet syndrome, focusing on seizure frequency and cognitive improvements [6] - Data from the Phase 1/2a and ongoing open-label extension studies will be presented at the 2025 American Epilepsy Society Annual Meeting [2][3] Disease Context - Dravet syndrome is characterized by severe seizures and cognitive impairments, with a significant portion of patients not achieving adequate seizure control with existing treatments [4] - Approximately 38,000 individuals are estimated to be living with Dravet syndrome in the U.S., UK, EU-4, and Japan [4]