Dow Dips 200 Points; Q32 Bio Shares Jump

Market Overview - U.S. stocks traded lower, with the Dow Jones falling approximately 200 points, down 0.42% to 47,515.41, NASDAQ down 1.08% to 23,113.36, and S&P 500 down 0.68% to 6,802.39 [1] - European shares were mostly lower, with the eurozone's STOXX 600 down 0.4%, Spain's IBEX 35 Index down 0.1%, London's FTSE 100 up 0.1%, Germany's DAX 40 down 1.1%, and France's CAC 40 down 0.4% [5] - Asian markets closed mixed, with Japan's Nikkei down 1.89%, Hong Kong's Hang Seng up 0.67%, China's Shanghai Composite up 0.65%, and India's BSE Sensex down 0.08% [6] Economic Indicators - The S&P Global manufacturing PMI was revised higher to 52.2 in November from a preliminary reading of 51.9, but down from October's final reading of 52.5 [2][7] Commodity Market - Oil traded up 1.7% to $59.53, gold up 0.2% to $4,261.40, silver up 0.9% to $57.62, and copper rose 0.8% to $5.3150 [4] Company Performance - Q32 Bio Inc. shares surged 171% to $5.91 after selling its Phase 2 complement inhibitor ADX-097 to Akebia for $12 million upfront and potential milestone and royalty payments up to $592 million [8] - Ambitions Enterprise Management Co. L.L.C shares increased 102% to $9.75 [8] - KALA BIO, Inc. shares rose 47% to $1.42 after securing a $6 million securities purchase agreement and appointing David Lazar as CEO and Chairman [8] - Paranovus Entertainment Technology Ltd. shares dropped 81% to $0.1996 [8] - CN ENERGY GROUP Inc shares fell 18% to $1.19 after announcing the launch of PATHENBOT Robotics Solutions Platform [8] - Rubico Inc shares decreased 19% to $0.13 following a 1-for-30 reverse stock split [8]