三维类器官展现发育中肢体关键特征 为人体组织修复提供新思路

Core Insights - A new three-dimensional organoid named "Budoid" has been developed by a team at the Swiss Federal Institute of Technology in Lausanne, showcasing key features of limb development, including symmetry breaking and early cartilage formation [1][2] Group 1: Research and Development - The research published in the latest issue of "Science Advances" highlights the role of chemical signaling between different cell types during early embryonic development, particularly in limb formation [1] - The study addresses the challenges of researching the short-lived Apical Ectodermal Ridge (AER) cells, which guide the growth of underlying cells to form bones, cartilage, and connective tissues [1] - The team cultivated a mixed cell population from mouse embryonic stem cells that naturally formed AER, surface ectoderm, and mesoderm cells, covering all major cell types involved in limb development [1] Group 2: Applications and Implications - "Budoid" provides a novel practical system for exploring difficult areas in embryonic development, such as how cells coordinate behavior, how early structures develop, and how cartilage forms [2] - The potential applications of this research extend beyond basic studies to congenital disease modeling, testing chemicals that may impair limb development, and even promoting regenerative medicine applications [2]