Pfizer Reaffirms Full-Year 2025 EPS Guidance and Provides Full-Year 2026 Guidance

Core Insights - Pfizer Inc. has provided its full-year 2026 revenue guidance, projecting revenues between $59.5 billion and $62.5 billion, while revising its 2025 revenue guidance to approximately $62.0 billion from a previous range of $61.0 billion to $64.0 billion [2][5] - The 2026 revenue guidance reflects an expected decrease of approximately $1.5 billion from COVID-19 products compared to 2025, along with a similar negative impact due to loss of exclusivity for certain products [2][11] - Pfizer anticipates operational revenue growth of about 4% year-over-year at the midpoint for 2026, excluding COVID-19 and loss of exclusivity products [2] Financial Guidance for 2026 - Adjusted Selling, Informational & Administrative (SI&A) expenses are expected to be between $12.5 billion and $13.5 billion, while Adjusted R&D expenses are projected to be between $10.5 billion and $11.5 billion, leading to total adjusted expenses of $23.0 billion to $25.0 billion for 2026 [3] - Adjusted diluted EPS for 2026 is anticipated to be in the range of $2.80 to $3.00, reflecting stable gross and operating margins compared to 2025 and a higher effective tax rate [4][5] Comparison of Financial Guidance - The revised 2025 financial guidance includes revenues of approximately $62.0 billion, down from the previous range, with COVID-19 product revenues expected to be around $6.5 billion [5] - Adjusted SI&A expenses for 2025 are projected at $13.1 billion to $14.1 billion, while Adjusted R&D expenses are estimated at $10.0 billion to $11.0 billion [5] - The effective tax rate on adjusted income for 2025 is approximately 11%, compared to an expected 15% for 2026 [5] CEO Commentary - The CEO emphasized that 2025 was a year of strong execution and strategic progress, positioning the company for sustainable growth in the post-loss of exclusivity period [7]