成都创新突破入选《科学》年度十大突破

Group 1 - The core achievement highlighted is the successful transplantation of a genetically modified pig kidney, which maintained function for 261 days, significantly exceeding early clinical expectations [1][2] - The genetically modified pig, developed by Chengdu Zhongke Aoge Biotechnology Co., had six genes edited to reduce immunogenicity, providing a new pathway to address global organ shortages [1][2] - The procedure was performed by a team from the Air Force Military Medical University, marking it as the first in Asia and the fifth globally for gene-edited pig kidney transplantation [1] Group 2 - The donor pig had three key antigen genes knocked out to prevent hyperacute and acute rejection, while three human protein genes were introduced to suppress immune attacks and prevent coagulation disorders [2] - This "six-gene editing" approach achieved comparable clinical outcomes to more complex international gene editing methods, showcasing a clear technical advantage [2] - The successful function of the transplanted kidney allowed the patient to avoid dialysis treatment, providing valuable long-term data for global xenotransplantation research [2]