新研究：过量摄入山梨糖醇或致肝脏受损

Core Insights - A recent study from Washington University in St. Louis indicates that sorbitol, a common sugar substitute, can be converted into fructose in the liver, and excessive intake may lead to liver damage similar to that caused by high fructose consumption [1][2] Group 1: Health Implications - Sorbitol is often marketed as a healthier alternative to sugar, with many consumers turning to sugar substitutes to mitigate health risks associated with sugar [1] - Previous research has linked excessive fructose intake to liver lipid accumulation, posing a risk for fatty liver disease [1] Group 2: Research Findings - The study utilized zebrafish in animal experiments, revealing that certain gut bacteria can break down sorbitol into harmless metabolites [1] - If the gut lacks these beneficial bacteria, undigested sorbitol is transported to the liver, where it is converted into fructose, potentially impairing liver function [1] Group 3: Dietary Sources - Some fruits naturally contain sorbitol, and glucose in certain foods can be converted into sorbitol through enzymatic action in the gut [1] - The findings suggest that excessive consumption of sorbitol as a sugar substitute may increase the risk of liver disease [1]