高脂饮食悄然改写肝脏细胞命运

Core Insights - A study from MIT reveals that high-fat diets can drive liver cells into an immature state, which may lead to liver cancer development [1][2] - The research indicates that under high-fat stress, liver cells activate survival genes while shutting down those necessary for normal liver function, creating a risk for cancer [2] Group 1: Mechanism of Cancer Development - Liver cells under high-fat conditions revert to a stem cell-like state, which helps them survive but increases the risk of cancer [1] - The study utilized single-cell RNA sequencing to track the progression from liver inflammation and fibrosis to cancer in mice [1] Group 2: Human Implications - Similar mechanisms were observed in human liver disease patients, where higher expression of survival genes correlated with poorer prognosis and shorter survival after tumor development [2] - The timeline for cancer development in humans may extend up to 20 years, influenced by diet, alcohol intake, and viral infections [2] Group 3: Future Research Directions - Future research will explore whether switching to a healthy diet or using GLP-1 weight loss drugs can reverse the changes in liver cells [3] - The study has identified a transcription factor named SOX4 as a potential target for intercepting the cancer progression process [3]