加深对大脑神经回路运作方式的理解 工程蛋白让人类“听到”神经元交流

Core Insights - Scientists from the Allen Institute and the Howard Hughes Medical Institute have developed a special protein called iGluSnFR4, which serves as a molecular "glutamate indicator" for real-time observation of neuronal communication in the brain [1][2] - This breakthrough aids in deciphering the hidden "language" of the brain and enhances understanding of its complex neural circuitry [1] Group 1: Technological Advancements - iGluSnFR4 addresses the challenge of previously only being able to record signals emitted by neurons, allowing scientists to "hear" the input signals that neurons receive [2] - The protein is highly sensitive to glutamate, enabling the detection of the weakest input signals between neurons, thus providing new pathways for analyzing the complex cascade of electrical activities that support learning, memory, and emotions [2] Group 2: Implications for Neurological Research - Abnormal glutamate signaling is associated with various neurological disorders, including Alzheimer's disease, schizophrenia, autism, and epilepsy [2] - The ability to observe synaptic activity more precisely with iGluSnFR4 allows for deeper investigation into the mechanisms underlying these diseases [2]