【新华社】新技术有望探明胚胎移植失败原因

Core Viewpoint - The research team from the Chinese Academy of Sciences has developed a 3D human embryo implantation model that successfully replicates the entire process of human embryo implantation in vitro, which may help identify the causes of repeated implantation failure (RIF) in assisted reproductive technology [6][9]. Group 1: Research Findings - Approximately 10% of patients undergoing assisted reproductive technology experience clinical pregnancy failure after three embryo transfers, with factors such as embryo quality, endometrial condition, and immune response potentially contributing to this issue [7]. - The study found that RIF patients often have increased apoptotic cells and reduced proliferation ability in their endometrial cells, indicating a less favorable environment for embryo implantation [7]. - The implantation rates of blastocysts in RIF patients were lower compared to healthy individuals, correlating with clinical observations of "successful transfers but embryo arrest" [7]. Group 2: Technological Innovations - The new technology allows for the construction of an artificial endometrial model using endometrial cells obtained from menstrual blood, achieving a 94% similarity in gene expression to biopsy samples, thus enhancing patient acceptance due to its non-invasive nature [7]. - The research team has developed a microfluidic chip that simulates the pathological abnormalities of embryo implantation, enabling more precise identification of causes for implantation failure [7][9]. Group 3: Implications for Clinical Practice - The 3D embryo implantation model bridges basic research and clinical application, providing practical diagnostic tools for clinicians in the field of reproductive medicine [9]. - The research team has tested 1,119 FDA-approved drugs, paving the way for personalized drug screening for patients, which could enhance the precision of assisted reproductive technologies [9].