动物模型显示阿尔茨海默病或可被逆转

Core Insights - A new study challenges the long-held belief that Alzheimer's disease is irreversible, suggesting that restoring brain energy balance can help reverse the disease in mice and restore cognitive function [1] Group 1: Research Findings - Researchers from Case Western Reserve University and other institutions found that the imbalance of NAD+ levels in the brain is a key factor driving the development of Alzheimer's disease [1] - The study indicates that NAD+ levels naturally decline with aging, and this decline is more severe in the brains of Alzheimer's patients, as well as in mouse models of the disease [1] - Maintaining normal NAD+ levels in the brain can prevent the onset of Alzheimer's disease, and even in late-stage Alzheimer's, restoring NAD+ balance can repair brain damage and recover cognitive function [1] Group 2: Implications - The findings suggest that maintaining brain energy balance may not only help prevent and slow Alzheimer's disease but could potentially reverse the condition, offering new hope for recovery [1] - Further clinical trials are needed to validate the effectiveness of related therapies in humans [1]