仅次于流感，这种病毒流行强度增强，近两月中招人数比去年多5倍

Core Viewpoint - The incidence of hand, foot, and mouth disease (HFMD) in China has significantly increased this year, particularly in the autumn season, surpassing the spring and summer peaks observed in previous years [1][2][3]. Summary by Sections Incidence Data - In November, Guangdong reported 28,900 cases of HFMD, ranking second among class B infectious diseases, with influenza in the first position [1] - Nationally, HFMD cases reached 269,300 in November, with one reported death [1] - In October, the total number of HFMD cases was 388,700, with no deaths reported [2] - The cumulative cases for October and November 2025 reached 658,000, over six times the number from the same period in 2024 [2] Characteristics of HFMD - HFMD is characterized by rashes or blisters on the hands, feet, and mouth, primarily caused by enteroviruses, notably Coxsackie virus A16, A6, A10, and enterovirus A71 [2] - It is a common childhood infectious disease, especially in children under five years old, due to their underdeveloped immune systems [2] Observations and Symptoms - Clinical observations indicate that this year's HFMD cases exhibit more extensive rashes, affecting areas beyond the typical sites, including around the mouth and other body parts [3] - There has been a noted increase in cases this autumn compared to previous years, although a decrease in patients was observed entering December [3] Factors Contributing to Increased Incidence - The predominant strain this year is Coxsackie virus A6, which causes more severe symptoms and a wider range of rashes [4] - A study indicated that CVA6 has become a major pathogen for severe HFMD cases, with evolving strains posing a risk of outbreaks [4] - The EV-A71 vaccine, while effective against the most dangerous strain, does not provide cross-protection against other strains like CVA6, which complicates vaccine development [4][5] Vaccine Importance - The EV-A71 vaccine remains crucial for preventing severe cases and deaths associated with HFMD, despite its limitations against other strains [5]