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Core Viewpoint - The article emphasizes the importance of using the correct temperature and type of water when taking medication, particularly capsules, as using hot water can compromise drug efficacy and pose health risks [1][2]. Group 1: Medication Administration Guidelines - Hot water, especially above 40°C, can damage the efficacy of certain medications, particularly enteric-coated capsules, leading to gastrointestinal discomfort and ineffective treatment [1]. - Capsules, which account for about 20% of prescriptions, are sensitive to heat; gelatin capsules can soften and become sticky in water above 50°C, potentially causing them to dissolve prematurely in the esophagus [1]. - It is recommended to use room temperature or cool water for taking capsules, and to avoid hot water to prevent softening of the capsule shell [1][2]. Group 2: Risks Associated with Improper Water Temperature - Using hot water can lead to esophageal damage, especially with irritating medications like doxycycline and ibuprofen, as the capsule may dissolve too early [1]. - Enteric-coated capsules are designed to protect the drug from stomach acid; using hot water can compromise this protective layer, leading to gastric irritation and ineffective drug absorption [1]. - Some medications require specific storage conditions; for example, soft capsules should be stored at 8°C to 20°C, and using hot water can increase the risk of degradation [1]. Group 3: Recommendations for Specific Medications - Certain medications, such as vitamins and digestive aids, should not be taken with hot water as heat can degrade their effectiveness [1][2]. - Medications containing live bacteria should be taken with cool or warm water, and hot water can kill the active cultures [1]. - After taking capsules, it is advisable to wait before consuming hot beverages to avoid compromising the medication [1]. Group 4: General Medication Taking Practices - It is important to maintain an upright position for at least 5-10 minutes after taking medication to reduce the risk of esophageal injury [2]. - When taking multiple medications, it is advisable to consult a pharmacist to avoid interactions and ensure proper timing between doses [2]. - Crushing or splitting medications should only be done if specified in the instructions or under professional guidance [2].