动物实验显示： 药物能逆转阿尔茨海默病进程

Core Insights - A recent study by American scientists reveals that energy supply imbalance in the brain is a significant factor in the progression of Alzheimer's disease, suggesting a potential for reversing the disease process [1][2] - The research indicates that the drug P7C3-A20 can restore the balance of a key cellular energy molecule, NAD+, leading to the repair of damaged brain tissue and full recovery of memory and cognitive functions in late-stage mice [1][2] Group 1 - The study marks a shift in Alzheimer's research focus from prevention or slowing progression to functional recovery [2] - The research team utilized mouse models and human brain tissue to identify that Alzheimer's patients struggle to maintain normal levels of NAD+, which directly contributes to disease progression [1] - The results showed that after restoring energy balance, cognitive functions in mice were fully recovered, and biomarkers associated with Alzheimer's returned to normal levels [1] Group 2 - The therapy differs from common NAD+ supplements, which may increase cancer risk by excessively raising NAD+ levels; P7C3-A20 precisely regulates NAD+ balance under cellular stress [2] - This discovery opens new avenues for Alzheimer's treatment and lays the groundwork for future human trials [2] - The research team plans to further explore the mechanisms of brain energy balance and assess the therapy's applicability to other age-related neurodegenerative diseases [2]