InSilico Medicine Debuts on HKEX With Market Cap Exceeding ~US$2.4B, Leading the Year’s Largest Biotech IPO in Hong Kong

Core Insights - InSilico Medicine Cayman TopCo became the first AI-driven biopharmaceutical company to list on the Main Board of the Hong Kong Stock Exchange under Rule 8.05 on December 30, 2025 [1] IPO Highlights - The IPO raised HK$2.277 billion (approximately US$294 million), marking it as the largest biotech IPO in Hong Kong by proceeds in 2025 [2] - The Hong Kong public offering was oversubscribed by 1,427.37 times, with over HK$328.35 billion (approximately US$42.4 billion) frozen in capital, while the international tranche was oversubscribed by 26.27 times, both ranking first among peer IPOs this year [2] Investor Interest - The company attracted 15 global cornerstone investors, including notable firms such as Eli Lilly and Company, Tencent, Temasek, and Schroders [3] Stock Performance - On debut, shares surged by 42.04% from the offer price, reaching HK$34.16 (approximately US$4.41) by 11:00 a.m., valuing the company at over HK$19 billion (approximately US$2.4 billion) [3] Company Overview - Founded in 2014, InSilico Medicine operates a dual-engine model based on its proprietary Pharma.AI platform, which combines AI platform licensing with internal drug pipeline development [4] - The company has established a pipeline of over 30 innovative programs [4] Key Drug Development - The flagship asset, Rentosertib (ISM001-055), is a TNIK-targeting drug candidate for idiopathic pulmonary fibrosis (IPF) discovered entirely using AI [5] - In April 2025, Rentosertib was recommended for Breakthrough Therapy Designation by China's Center for Drug Evaluation (CDE) and is expected to move directly into Phase III clinical trials after completing Phase IIa trials, potentially becoming the world's first fully AI-discovered drug to enter Phase III [5] Financial Performance - Revenue grew from US$30.15 million in 2022 to US$85.83 million in 2024, with gross margin expanding from 63.4% to 90.4% [6] - Net losses narrowed significantly from US$222 million to US$17.1 million during the same period [6] - The company plans to allocate approximately 48% of IPO proceeds towards advancing key clinical-stage programs [6]