注意！一“疼”就吃的这种药 可能悄悄损伤胃和肾

Core Viewpoint - Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) in China, accounting for nearly 25% of the analgesic market, but long-term or excessive use may lead to gastrointestinal and kidney damage [1][2]. Group 1: Usage and Mechanism - Ibuprofen is effective for relieving pain (such as headaches, toothaches, and post-exercise injuries), treating fever, primary dysmenorrhea, and joint pain caused by bone and joint diseases [5]. - The mechanism of ibuprofen involves the precise inhibition of cyclooxygenase (COX) activity, reducing the synthesis of prostaglandins, thereby diminishing pain signal transmission and achieving antipyretic, analgesic, and anti-inflammatory effects [2][4]. Group 2: Risks of Long-term Use - Long-term or excessive use of ibuprofen can lead to gastrointestinal discomfort, including symptoms like stomach pain, ulcers, and bleeding, particularly in individuals with a history of gastrointestinal diseases, older adults, and those taking other NSAIDs or alcohol [4][7]. - Kidney function damage is a risk for individuals with pre-existing kidney conditions, the elderly, dehydrated individuals, and those on long-term high doses or other nephrotoxic medications [7]. Group 3: Usage Guidelines - Ibuprofen should not be used for more than 3 days for fever and 5 days for pain relief without consulting a healthcare professional if symptoms persist [8]. - It is recommended to take ibuprofen during or after meals to minimize gastrointestinal irritation [8]. - Different formulations of ibuprofen have specific usage instructions, such as not crushing extended-release forms and ensuring liquid forms are well-shaken before use [8][9]. Group 4: Contraindications - Certain populations should avoid ibuprofen, including individuals allergic to ibuprofen or other NSAIDs, pregnant or breastfeeding women, and those with active gastrointestinal ulcers or bleeding [11].