应对老龄化浪潮 专家呼吁构建神经疾病全链条防治体系

Core Viewpoint - The increasing prevalence of neurodegenerative diseases in China, particularly Parkinson's and Alzheimer's, necessitates the establishment of a comprehensive and efficient diagnostic and treatment system that encompasses early warning, precise intervention, full management, and social support [1][2]. Group 1: Current Challenges in Diagnosis and Treatment - There are over 5 million Parkinson's disease patients in China, with a significantly larger number of potential patients, highlighting the critical issue of irreversible brain cell damage occurring before clinical symptoms appear [2]. - Early diagnosis and differential diagnosis of Parkinson's disease face significant challenges, with multiple dimensions such as clinical treatment, genetic information analysis, molecular imaging application, and protein research still presenting numerous scientific and clinical hurdles [2][3]. Group 2: Technological Innovations - A breakthrough in early diagnosis has been achieved with the development of a serum α-synuclein ultra-sensitive detection technology, which requires only 2 milliliters of blood and boasts a 95% accuracy rate for diagnosing Parkinson's spectrum diseases [2][3]. - This technology is a disruptive alternative to brain biopsy and allows for early diagnosis of neurodegenerative diseases up to five years before symptoms manifest, providing essential support for early intervention [2][3]. Group 3: Institutional Development and Innovation - Guangzhou Medical University First Affiliated Hospital emphasizes the importance of transforming from a "follower" to a "leader" in medical innovation, with a clear plan to build a research-oriented hospital and develop a diverse academic discipline system [4][5]. - The hospital is committed to ensuring that research outcomes meet the standards of being high-quality, cost-effective, and widely accessible, which is crucial for improving healthcare quality and reducing societal medical costs [5]. Group 4: Future Directions and Standardization - Experts call for the establishment of a comprehensive brain health management system covering the entire life cycle, with plans to integrate high-quality resources across the province for standardization, technology promotion, talent cultivation, and multi-center research [6]. - The team is working towards developing standardized testing kits for high-throughput detection and plans to promote this innovative technology internationally through the "Belt and Road" initiative [6].