科普丨阿司匹林能否长期大量服用

Core Viewpoint - Aspirin is widely used for the prevention of cardiovascular diseases, especially among the elderly, but its long-term use and potential side effects require careful consideration and medical guidance [1][2][3]. Group 1: Aspirin's Applications - Aspirin was initially used as an analgesic and anti-inflammatory drug but is now recognized for its ability to inhibit platelet aggregation, making it effective in preventing thrombosis [1]. - It is a standard treatment for various atherosclerotic diseases, including coronary heart disease, cerebrovascular disease, and peripheral vascular disease [1]. - Additionally, aspirin is used to prevent preeclampsia during pregnancy and to treat antiphospholipid syndrome [1]. Group 2: Proper Usage and Dosage - To minimize gastric irritation, enteric-coated aspirin has been developed, which dissolves in the intestine rather than the stomach [2]. - The recommended method for taking enteric-coated aspirin is on an empty stomach, followed by eating after 30 minutes, while regular aspirin should be taken after meals [2]. - Daily aspirin intake may reduce the risk of heart attacks and strokes, but it is not suitable for everyone and should be taken under medical advice [2]. Group 3: Risks and Considerations - There is increasing concern about the bleeding risks associated with aspirin, particularly in the elderly, necessitating careful assessment of its indications and contraindications [3]. - Long-term aspirin use can be beneficial for elderly patients with atherosclerotic diseases or high cardiovascular risk, provided that risks are properly evaluated [3]. - For most adults, occasional aspirin use for pain relief is generally safe, but daily use without a history of heart disease may not provide significant benefits and could lead to serious side effects [3].