Small-Cap Standouts: These 3 Stocks Rose Over 300% in 2025

Core Insights - In 2025, small-cap stocks underperformed compared to large-cap stocks, with the Russell 2000 Index delivering a total return of approximately 13%, while the S&P 500 Index achieved around 18% [2] - Despite the overall underperformance, three small-cap stocks achieved exceptional returns of 300% or more, transitioning into mid-cap status [3] Company Performance - GRAIL, a healthcare company focused on early cancer detection, saw its stock price increase by approximately 380% in 2025, raising its market capitalization from below $1 billion to around $3.3 billion [3] - GRAIL's main product, the Galleri Multi-Cancer Early Detection test, is designed to detect over 50 types of cancer, significantly improving early detection rates [4] - The company plans to apply for Premarket Approval (PMA) from the U.S. FDA in Q1 2026, which could lead to commercial insurers covering the test, unlocking a new sales channel [5] Market Outlook - Analysts have a consensus price target of $97.50 for GRAIL, indicating an optimistic outlook with an implied upside of around 14% [6]