老年人生物钟紊乱或增加痴呆症风险

Core Findings - A new study indicates that weakened or irregular circadian rhythms in older adults may increase the risk of dementia, as published in the journal Neurology [1][2] - Circadian rhythms regulate various physiological processes, and their disruption can lead to health issues, potentially serving as a risk factor for neurodegenerative diseases like dementia [1] Study Details - The research involved 2,183 participants with an average age of 79, all of whom were dementia-free at the start of the study [1] - Participants wore monitoring devices for an average of 12 days to assess the strength and regularity of their circadian rhythms, categorized into high, medium, and low amplitude groups [1] Follow-Up Results - Over an average follow-up period of 3 years, 176 participants were diagnosed with dementia, approximately 8% of the total [2] - Among the high amplitude group of 728 individuals, 31 developed dementia, while 106 out of 727 in the low amplitude group were diagnosed [2] - After adjusting for factors such as age, blood pressure, and heart disease, the risk of dementia in the low amplitude group was found to be 2.5 times higher than that in the high amplitude group [2]