新研究揭示大脑早期发育遗传机制

Core Insights - A recent study by researchers at the Hebrew University of Jerusalem reveals genetic mechanisms involved in early brain development and identifies a previously unknown pathogenic gene linked to childhood neurodevelopmental disorders [1][2] Group 1: Research Findings - The study, conducted in collaboration with the French National Institute of Health and Medical Research, utilized CRISPR gene-editing technology to systematically "turn off" nearly 20,000 genes during the differentiation of embryonic stem cells into neurons, creating a "functional map" of essential genes for brain development [1] - A total of 331 genes were identified as crucial for normal neuron formation, with many of these genes previously unrecognized in relation to early brain development [1][2] - The research confirmed that the PEDS1 gene is a key factor in causing a specific neurodevelopmental disorder, as rare mutations in this gene were found in children with severe neurodevelopmental issues, including developmental delays and reduced brain volume [1] Group 2: Implications - The comprehensive mapping of genes necessary for brain development provides a significant tool for discovering additional genes associated with neurodevelopmental disorders [2] - This research lays the groundwork for understanding the mechanisms of brain development and establishes a genetic framework for early diagnosis and future precision treatment of neurodevelopmental disorders [2]