新研究显示减肥药停用后平均不到两年就会“打回原形”

Core Insights - A new study led by Oxford University indicates that the effects of weight loss medications diminish within an average of two years after discontinuation, emphasizing the importance of maintaining healthy exercise and dietary habits to sustain weight loss [1][4] Group 1: Study Findings - The analysis involved data from 9,341 participants across 37 studies, all of whom were overweight or obese and used a total of 18 different weight loss drugs, with an average treatment duration of 39 weeks and a follow-up period of 32 weeks post-treatment [1] - Participants experienced an average weight rebound of 0.4 kg per month after stopping the medication, leading to an estimated return to baseline weight in approximately 1.7 years [1] - Health benefits such as reduced blood pressure and cholesterol levels also reverted to pre-treatment levels within an average of 1.4 years after stopping the medication [1] Group 2: GLP-1 Medications - Half of the participants used GLP-1 medications, with 1,776 individuals taking newer, more effective drugs like semaglutide and tirzepatide, which can help individuals lose 15% to 20% of their body weight in the short term [2] - However, many users discontinue these medications within a year due to side effects and high costs, resulting in a faster weight rebound of nearly 0.8 kg per month, with an estimated return to baseline weight in about 1.5 years [2] Group 3: Implications for Healthcare Systems - The findings may influence how healthcare systems evaluate the cost-effectiveness of these medications, as the rebound rate for those using weight loss drugs is higher compared to those who lose weight through diet and exercise [3] - Individuals using non-drug methods take an average of four years to regain weight after stopping their weight loss efforts, likely due to the healthier habits they have developed [3]