Group 1 - Shandong has positioned technological innovation at the core of its development strategy, achieving significant breakthroughs in 2025, including the establishment of a pilot verification platform to address the industrialization challenges of trans-aconitic acid production [1] - Trans-aconitic acid is recognized as a high-quality bio-based raw material with applications in modern agriculture and high-end chemical industries, but large-scale industrial production has been a global challenge due to high costs of plant extraction and severe pollution from chemical synthesis [1] - The Chinese Academy of Sciences' Qingdao Institute of Energy has developed a method to synthesize trans-aconitic acid using genetically engineered microorganisms, achieving continuous technological breakthroughs from low to high yields [1] Group 2 - The establishment of a 10-ton pilot platform has been supported by provincial scientific funding, which is essential for scaling up production and addressing technical uncertainties [1][2] - The updated "Manufacturing Industry Pilot Platform Construction Guidelines" in 2025 aims to encourage leading enterprises to build pilot platforms, facilitating product research, design, and testing [2] - A partnership between LuKang Pharmaceutical and the Qingdao Institute of Energy has been formed to inject funding into the promotion and application of this new technology [2] Group 3 - The pilot platform allows for significant scaling from laboratory to industrial production, with investments around 3.5 million yuan for fermentation tanks ranging from 15L to 10 cubic meters [2] - The production process for trans-aconitic acid has been optimized to achieve a hundred-ton level of mass production, completing the entire extraction process in approximately 24 hours [3] - Shandong has established 40 provincial pilot demonstration bases and 6 provincial concept verification centers, completing 284 pilot projects and promoting 259 achievements for industrialization in the first half of 2025 [3]
2025回顾·新科技新产品记|搭建中试平台,解决反式乌头酸工业化生产世界难题