中国专家探索借mRNA技术建“活性心脏创口贴” 为心衰治疗提供新策略

Core Insights - Chinese medical experts have proposed a new strategy for heart failure treatment by combining mRNA technology with human-induced pluripotent stem cell-derived cardiomyocyte precursor cells to create a cardiac patch [1][2] - The research demonstrated that IGF1 mRNA-modified cardiac patches significantly improve graft survival rates and promote heart function recovery, revealing potential mechanisms behind these effects [1][2] Group 1: Research Background - Heart failure is one of the leading causes of death globally, and while significant advancements have been made in drug therapy, interventional, and surgical treatments, effective options for end-stage heart failure patients primarily rely on heart transplantation [1] - Limitations in heart transplantation include donor shortages and rejection reactions post-surgery, which restrict clinical applications [1] Group 2: Innovative Treatment Method - The emerging treatment method involves engineering cardiac patches by first obtaining a sufficient number of cardiomyocytes through directed differentiation of human-induced pluripotent stem cells, followed by constructing the patches with biomaterials for surface application on the heart [2] - The research addresses the critical challenge of enhancing the survival rate of transplanted cells within the cardiac patches, which is essential for improving treatment outcomes [2] Group 3: Research Achievements - The study led by researchers Fu Wei and Wang Wei has been recognized by being selected for the finals of the 2024 National Disruptive Technology Innovation Competition [2]