Oncolytics Biotech (ONCY) Leadership Strengthens As Pelareorep Advances

Group 1: Leadership and Strategic Developments - Oncolytics Biotech Inc. has strengthened its leadership by appointing Dr. Eileen O'Reilly, Dr. Neil Segal, and Dr. Van Morris to its Gastrointestinal Tumor Scientific Advisory Board, enhancing clinical and strategic oversight as the company advances pelareorep toward registration-enabling trials in pancreatic, colorectal, and anal cancers [2] - The expanded advisory board is expected to sharpen the late-stage development strategy for a GI-focused immunotherapy platform, which targets large addressable markets [2] Group 2: Clinical and Translational Momentum - Recent data from clinical trials in second-line KRAS-mutant, microsatellite-stable metastatic colorectal cancer showed a 33% objective response rate, significantly higher than the historical rate of 6-11% [3] - The trials also demonstrated more than double the progression-free and overall survival compared to standard therapy, indicating strong efficacy of pelareorep [3] - Translational analysis revealed increased KRAS-specific T-cell responses, reinforcing the mechanistic differentiation of pelareorep [3] Group 3: Company Focus and Technology - Oncolytics Biotech is focused on developing pelareorep, an immune-oncolytic virus platform that targets solid tumors and hematologic malignancies, utilizing tumor-selective viral replication to stimulate both innate and adaptive anti-cancer immune responses [4]