Zydus Lifesciences Limited completes the acquisition of Agenus Inc.'s biologics manufacturing facilities, launches Zylidac Bio LLC in the U.S.

Core Insights - Zydus Lifesciences Limited has successfully closed multiple agreements with Agenus Inc., including an Asset Purchase Agreement, Share Purchase Agreement, and an exclusive Licensing Agreement, following necessary regulatory approvals [1] - The transaction establishes Zydus' advanced manufacturing capabilities in the global biologics contract development and manufacturing organization (CDMO) sector through a new subsidiary, Zylidac Bio LLC [2] Group 1: Strategic Importance - Zylidac Bio LLC will provide biological manufacturing sites offering CDMO services to biopharmaceutical companies globally, supporting the U.S. landscape for secure and high-quality supply chains for advanced therapies [3] - The collaboration enhances Agenus' immunotherapy pipeline and U.S.-based clinical development capabilities while allowing Zydus to leverage its global manufacturing and commercial infrastructure [3] Group 2: Regulatory and Market Context - The establishment of Zylidac Bio LLC aligns with the BIOSECURE Act, which restricts U.S. agencies from contracting with certain biotechnology companies, thus providing a compliant manufacturing option for global biopharmaceutical firms [3] - Zydus has secured exclusive rights to commercialize Agenus' lead immuno-oncology assets, Botensilimab and Balstilimab, in India and Sri Lanka, enhancing its market position [4] Group 3: Financial and Operational Developments - Zydus completed an equity investment in Agenus Inc. through its venture capital arm, Zynext Ventures, complementing its strategic partnership with Formycon for a Keytruda® biosimilar [5] - The localized supply chain established by Zylidac Bio LLC ensures agility and security for Zydus' expanding biosimilar and innovative product portfolio [5]