如何精准清除“致病蛋白”？中国科学家创新研发开辟新路径

Core Insights - Chinese scientists have developed a novel approach to precisely eliminate "pathogenic proteins" using a supramolecular targeted chimeric system (SupTAC), marking a significant advancement in protein homeostasis regulation and disease treatment research [1][3]. Group 1: Research Breakthrough - The research team led by Wang Ming has successfully created a stable and functionalizable supramolecular nanoparticle through metal-organic cage multi-level self-assembly technology [3]. - This innovation allows for precise regulation of ubiquitination modification and degradation of target proteins, overcoming challenges faced by traditional methods in controlling the timing of protein degradation [3]. Group 2: Applications and Implications - The supramolecular targeted chimeric system exhibits programmable characteristics and spatial organization selectivity, enabling precise protein degradation within specific time windows [3]. - This breakthrough not only provides a new strategy for protein homeostasis regulation in complex biological systems but also shows significant potential in disease mechanism analysis and the discovery of innovative drug targets, paving the way for clinical applications of targeted protein degradation technology [3].