如何精准清除“致病蛋白”？我国科研团队开辟新路径

Core Viewpoint - The research team from the Chinese Academy of Sciences has developed a novel supramolecular targeted chimeric system that enables programmable and spatiotemporally controlled degradation of pathogenic proteins in live animals, marking a significant advancement in protein homeostasis regulation and disease treatment [1][4][5] Group 1: Technology Innovation - The targeted protein degradation technology utilizes the natural proteasome system to selectively eliminate pathogenic proteins by regulating their ubiquitination, providing a new strategy for protein clearance [4] - The innovative supramolecular chimeric system integrates supramolecular chemistry with cutting-edge protein chemical biology, resulting in stable, functionalizable supramolecular nanoparticles [4] Group 2: Performance and Applications - The supramolecular targeted chimeric system demonstrates stable and efficient spatiotemporal control of protein degradation across various models, including non-human primates, overcoming the limitations of traditional targeted protein degradation technologies [5] - This breakthrough not only offers a new strategy for protein homeostasis regulation in complex biological systems but also shows significant potential for applications in disease mechanism analysis and the discovery of innovative drug targets, paving the way for clinical translation of targeted protein degradation technologies [5]