我科学家在活体动物中实现时空可控的蛋白质精准降解

Core Viewpoint - The research team from the Chinese Academy of Sciences has developed a new supramolecular targeted chimeric (SupTAC) that enables precise degradation of pathogenic proteins in vivo, offering a novel tool for drug development and disease treatment [1][2]. Group 1: Research and Development - The SupTAC technology combines supramolecular chemistry with protein degradation techniques, resulting in a stable and flexibly assembled supramolecular nanoparticle [1]. - SupTAC's surface can be equipped with various functional modules, allowing for targeted and controlled protein degradation [1]. Group 2: Applications and Implications - Research indicates that SupTAC demonstrates stable, efficient, and spatiotemporally controllable protein degradation across various animal models, including non-human primates [2]. - This innovation provides a new strategy for precise regulation of protein balance within living organisms and shows significant potential for revealing disease mechanisms and discovering new drug targets [2].