超声脑机接口来了！胶质母细胞瘤治疗将迎关键突破

Core Viewpoint - The article discusses a breakthrough in medical technology that allows for the safe opening and closing of the blood-brain barrier (BBB) using an ultrasound device called UltraBrainPad, which enhances drug delivery for treating glioblastoma patients [1][2]. Group 1: Technology and Methodology - The UltraBrainPad device enables real-time observation of the brain using a handheld ultrasound probe, allowing doctors to select treatment targets and open the BBB with high precision [2]. - The research team optimized the ultrasound parameters to open the BBB in just 3 minutes, resulting in an average increase of 8 times in drug concentration compared to untreated brain tissue [1][2]. - The technology is described as a "ultrasound brain-machine interface," which not only facilitates drug delivery but also allows for the monitoring and adjustment of brain functions [2][3]. Group 2: Clinical Applications and Future Research - Glioblastoma accounts for approximately 30% of brain tumors, with an average survival time of around 16 months for patients [2]. - Future clinical trials will explore the application of this technology in treating other neurological diseases, including Alzheimer's and Parkinson's disease, as well as various functional neurological disorders [3]. - The research team plans to initiate the "ROAR-BBBO" clinical study to treat recurrent glioblastoma patients, aiming to expand the use of ultrasound brain-machine interface technology beyond drug treatment to include neural regulation and brain-machine integration [3].