Goldman Sachs Maintains Neutral on Pfizer (PFE) Amid Rising Margin Pressure

Core Insights - Pfizer Inc. (NYSE:PFE) is currently facing significant challenges, including a three-year period of rising patent-cliff strain impacting profit margins, a reduced business development capacity of $6 billion, and stagnant dividend growth for the first time in 16 years [1][3]. Group 1: Financial Performance - Pfizer ranks among stocks with the lowest forward PE ratios, indicating potential undervaluation in the market [1]. - The company’s profit margins are under pressure due to the patent expirations, which are expected to affect financial performance over the next three years [1]. Group 2: Future Catalysts - Goldman Sachs anticipates that a price rebound for Pfizer shares will likely be driven by clinical catalysts in 2026, particularly updates related to obesity treatments following Pfizer's recent acquisition [3]. - The upcoming VESPER-3 monthly data, expected to be released in the first half of 2026, is anticipated to be a significant driver for PFE shares this year [3]. Group 3: Business Overview - Pfizer Inc. is engaged in the discovery, development, manufacturing, marketing, distribution, and sale of biopharmaceutical products both in the US and internationally, offering a range of medicines and vaccines across various therapeutic areas [4].