研究发现非药物NSKSD纳豆激酶 可有效降低认知衰退风险

Core Viewpoint - A recent clinical study from China published in the Journal of Stroke and Cerebrovascular Diseases indicates that NSKSD nattokinase can effectively reduce the risk of cognitive decline in asymptomatic patients with intracranial/ carotid artery stenosis [1][2]. Group 1: Study Overview - The study, led by Professor Lou Min from Zhejiang University School of Medicine, involved a randomized double-blind placebo-controlled trial assessing the impact of NSKSD nattokinase on brain blood flow and cognitive function in patients with at least 50% stenosis [1][2]. - A total of 120 asymptomatic patients were enrolled, with 60 receiving NSKSD nattokinase (8000 FU daily) and 60 receiving a placebo for six months [2]. Group 2: Key Findings - The study found that the NSKSD nattokinase group showed a 65% reduction in the risk of cognitive decline in visual-spatial function compared to the placebo group [2]. - The average Z-score for visual-spatial function improved by 0.254 in the NSKSD group, while it decreased by 0.094 in the placebo group, resulting in a significant inter-group difference of 0.350 [2]. Group 3: Importance of Visual-Spatial Function - Visual-spatial ability is crucial for daily activities and its decline can lead to significant negative impacts on patients' lives, including difficulties in navigation and increased safety risks at home [3]. - Early intervention targeting visual function decline is essential for preventing vascular dementia, as it reflects the severity of cerebrovascular disease [3]. Group 4: Broader Implications - The study highlights the growing challenge of cerebrovascular and cognitive disorders in China, with a reported prevalence of mild cognitive impairment (MCI) at 20.8% among individuals aged 65 and older, with a significant portion attributed to cerebrovascular diseases [3]. - Traditional drug treatments face challenges such as adherence issues and side effects, making non-drug nutritional interventions like NSKSD nattokinase an important complementary approach in chronic disease prevention [4].